Diagnóstico incidental de tuberculosis pulmonar en pacientes remitidos para broncoscopia diagnóstica o seguimiento clínico por enfermedad tumoral maligna: un estudio transversal

Contenido principal del artículo

Jaime A. Echeverri-Franco
Jacobo Echeverri-Hoyos
Julian A. Hoyos-Pulgarin
Eduardo Tuta-Quintero

Resumen

Introducción: La tuberculosis pulmonar incidental se diagnostica inesperadamente en pacientes sin sospecha clínica previa, generalmente durante estudios por otras enfermedades. Existen pocos estudios sobre este tipo de diagnóstico. Describimos las características generales sobre el diagnóstico incidental de tuberculosis pulmonar en pacientes sometidos a broncoscopia por enfermedad neoplásica. Materiales y Métodos: Se llevó a cabo un estudio transversal en pacientes con diagnóstico incidental de tuberculosis pulmonar, identificado durante broncoscopias diagnósticas realizadas a personas con sospecha de cáncer o en seguimiento oncológico. El diagnóstico de tuberculosis se realizó utilizando la técnica GeneXpert  MTB/RIF. Resultados: Se incluyó un total de 18 pacientes, con una edad promedio de 50,3 años (DE: 20,4) y predominio de mujeres (55%; 10/18). Las comorbilidades más frecuentes fueron la diabetes mellitus (44%; 8/18) y la hipertensión arterial sistémica (44%; 8/18). El 17% (3/18) de los pacientes había recibido tratamientos oncológicos previos. Los síntomas más comunes asociados a la indicación del procedimiento fueron la pérdida de peso involuntaria (61,1%; 11/18). El 17% (3/18) presentó una prueba de tuberculina positiva, mientras que ninguno mostró baciloscopia positiva. Las tomografías de tórax revelaron infiltrados alveolares/intersticiales en el 50% (9/18), masas en el 28% (5/18), nódulos en el 22% (4/18) y adenopatías en el 28% (5/18). Discusión: La tuberculosis incidental ocurre en pacientes con sospecha de cáncer o en seguimiento oncológico. Es crucial considerar su diagnóstico diferencial en los estudios de broncoscopia.

Detalles del artículo

Sección
Articulos Originales

Citas

The end TB strategy.World Health Organization, Geneva, 2015.

Global tuberculosis report 2019.World Health Organization, Geneva, 2019.

WHO. Global tuberculosis report 2022 . Geneva Swizerland: World Health Organization; 2022. Report No.: 9240029435.

Ockenga J, Fuhse K, Chatterjee S, Malykh R, Rippin H, Pirlich M, et al. Tuberculosis and malnutrition: The European perspective. Clin Nutr. 2023 ;42(4):486-492. https://doi.org/10.1016/j.clnu.2023.01.016

Imtiaz S, Batubara EM. Diagnostic value of bronchoscopy in sputumnegative pulmonary tuberculosis patients and its correlation with clinicoradiological features. Ann Thorac Med. 2022 ;17(2):124-131. https://doi.org/10.4103/atm.atm_487_21

Bobosha K, Petros B, Howe R. Clinical and Imaging Characteristics of Smear Negative Pulmonary Tuberculosis Patients: A Comparative Study. Pulm Med. 2024 ;2024:2182088. https://doi.org/10.1155/2024/2182088

Wan T, Hu Q, Hu W, Deng H, Li D. Utility of Rapid On-Site Evaluation during Bronchoscopy in the Diagnosis of Pulmonary Tuberculosis. Acta Cytol. 2024;68(2):153-159. https://doi.org/10.1159/000538094

Kedige AR, Dinesh US. Role of Bronchoscopic Cytology in Diagnosis of Pulmonary Lesions. J Cytol. 2023 ;40(1):35-41. https://doi.org/10.4103/joc.joc_138_22

Morales-García C, Parra-Ruiz J, Sánchez-Martínez JA, Delgado-Martín AE, Amzouz-Amzouz A, Hernández-Quero J. Concomitant tuberculosis and lung cancer diagnosed by bronchoscopy. Int J Tuberc Lung Dis. 2015 ;19(9):1027-32. https://doi.org/10.5588/ijtld.14.0578

Ghildiyal S, Acharya S, Thakur B, Rawat J, Kumar R. Cytopathology of Pulmonary Lesions: A Tertiary Care Center Experience. J Cytol. 2018 OctDec;35(4):212-216. https://doi.org/10.4103/JOC.JOC_51_18

Zaidi A, Kaur H, Gupta P, Gupta N, Srinivasan R, Dey P, et al. Role of bronchoalveolar lavage in diagnosing pulmonary infections and malignancies: Experience from a tertiary care center. Diagn Cytopathol. 2020 ;48(12):1290-1299. https://doi.org/10.1002/dc.24574

Cuschieri S. The STROBE guidelines. Saudi J Anaesth. 2019 ;13(Suppl 1):S31-S34. https://doi.org/10.4103/sja.SJA_543_18

Brown S., Leavy J. E., Jancey J. Implementation of GeneXpert for TB testing in low- and middle-income countries: a systematic review. Global Health: Science and Practice . 2021;9(3):698-710. https://doi.org/10.9745/GHSP-D-21-00121

Pires MM, Pereira GR, Barbosa MS, Dias NJD, Secchi C, Hoff JS, et al. Association of Xpert MTB/RIF Cycle Threshold Values with Tuberculosis Treatment Outcomes. Lung. 2020 ;198(6):985-989. https://doi.org/10.1007/s00408-020-00398-3

Ngabonziza JCS, Decroo T, Maniliho R, Habimana YM, Van Deun A, de Jong BC. Low Cycle Threshold Value in Xpert MTB/RIF Assay May Herald False Detection of Tuberculosis and Rifampicin Resistance: A Study of Two Cases. Open Forum Infect Dis. 2021 ;8(2):ofab034. https://doi.org/10.1093/ofid/ofab034

Preda M, Tanase BC, Zob DL, Gheorghe AS, Lungulescu CV, Dumitrescu EA, et al. The Bidirectional Relationship between Pulmonary Tuberculosis and Lung Cancer. Int J Environ Res Public Health. 2023 ;20(2):1282. https://doi.org/10.3390/ijerph20021282

Cabrera-Sanchez J, Cuba V, Vega V, Van der Stuyft P, Otero L. Lung cancer occurrence after an episode of tuberculosis: a systematic review and meta-analysis. Eur Respir Rev. 2022 ;31(165):220025. https://doi.org/10.1183/16000617.0025-2022

Moon SM, Choi H, Kim SH, Kang HK, Park DW, Jung JH, et al. Increased Lung Cancer Risk and Associated Risk Factors in Tuberculosis Survivors: A Korean Population-Based Study. Clin Infect Dis. 2023 ;77(9):1329-1339. https://doi.org/10.1093/cid/ciad373

Luczynski P, Poulin P, Romanowski K, Johnston JC. Tuberculosis and risk of cancer: A systematic review and meta-analysis. PLoS One. 2022 ;17(12):e0278661. https://doi.org/10.1371/journal.pone.0278661

Jurczak P, Romaszko-Wojtowicz A, Doboszynska A. Lung Lesions: Differential Diagnoses Beyond Cancer. Am J Case Rep. 2024 ;25:e943798. https://doi.org/10.12659/AJCR.943798

Chu ZG, Sheng B, Liu MQ, Lv FJ, Li Q, Ouyang Y. Differential Diagnosis of Solitary Pulmonary Inflammatory Lesions and Peripheral Lung Cancers with Contrast-enhanced Computed Tomography. Clinics (Sao Paulo). 2016 ;71(10):555-561. https://doi.org/10.6061/clinics/2016(10)01

Saleemi SA, Alothman B, Alamer M, Alsayari S, Almogbel A, Mohammed S. Tuberculosis presenting as metastatic lung cancer. Int J Mycobacteriol. 2021 Jul- ;10(3):327-329. https://doi.org/10.4103/ijmy.ijmy_89_21

Sahin Mavi EA, Akdemir MC, Akin AE, Uyaroglu OA, Koksal D. Tuberculosis - The master of disguise: A case of disseminated tuberculosis masquerading as metastatic cancer. Tuberk Toraks. 2024 ;72(2):167-172. https://doi.org/10.5578/tt.202402915

Sossen B, Richards AS, Heinsohn T, Frascella B, Balzarini F, OradiniAlacreu A, et al. The natural history of untreated pulmonary tuberculosis in adults: a systematic review and meta-analysis. Lancet Respir Med. 2023 ;11(4):367-379. https://doi.org/10.1016/S2213-2600(23)00097-8

Craciun OM, Torres MDR, Llanes AB, Romay-Barja M. Tuberculosis Knowledge, Attitudes, and Practice in Middle- and Low-Income Countries: A Systematic Review. J Trop Med. 2023 ;2023:1014666. https://doi.org/10.1155/2023/1014666

Geadas C, Millones AK, Acosta D, Campos H, Del Aguila-Rojas E, Farroñay S, et al. Barriers and facilitators to tuberculosis diagnosis in Lima, Peru: a mixed methods study. BMC Infect Dis. 2024 ;24(1):798. https://doi.org/10.1186/s12879-024-09707-0

Datiko DG, Habte D, Jerene D, Suarez P. Knowledge, attitudes, and practices related to TB among the general population of Ethiopia: Findings from a national cross-sectional survey. PLoS One. 2019 ;14(10):e0224196. https://doi.org/10.1371/journal.pone.0224196

Mucheleng'anga LA, Himwaze CM, Telendiy V, Simumba S, Soko J, Kayonde N, et al. Incidental Tuberculosis in sudden, unexpected, and violent deaths in the community Lusaka, Zambia - A descriptive forensic post-mortem examination study. Int J Infect Dis. 2022 ;124 Suppl 1:S75-S81. https://doi.org/10.1016/j.ijid.2022.03.005

Yao L, Chen S, Sha W, Gu Y. The diagnostic performance of endobronchial ultrasound with Xpert MTB/RIF Ultra in smear-negative pulmonary tuberculosis. BMC Infect Dis. 2023 ;23(1):107. https://doi.org/10.1186/s12879-023-08073-7

Sobczak PA, Sobczak JM, Majewski S, Milkowska-Dymanowska J, Kurmanowska Z, Szewczyk K, et al. The role of bronchoscopy in diagnosis of chronic cough in adults: a retrospective single-center study. Adv RespirMed. 2020;88(5):406-411. https://doi.org/10.5603/ARM.a2020.0140

Artículos más leídos del mismo autor/a